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Cuijpers P, Sijbrandij M, Koole SL, Andersson G, Beekman AT, Reynolds III CF (2013). The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: A meta-analysis of direct comparisons. World Psychiatry, 12, 137-148.

Both psychotherapy and antidepressant medications are efficacious treatments for depression and anxiety disorders. However, there remains some debate about whether they are equally effective for all disorders, and whether psychotherapy and antidepressants are equally efficacious for each disorder. As I indicated in the March 2014 blog, antidepressant medications alone have become the first line of treatment for many who have depressive and anxiety disorders. However, a recent meta analysis concluded that monotherapy with medication alone was not optimal treatment for most patients, and that adding psychotherapy results in clinically meaningful improvement for most patients. Cuijpers and colleagues (2013) reported on an overall meta analysis of the studies in which psychotherapy and medication were directly compared to each other in adults with depressive disorders, panic disorder, generalized anxiety disorder (GAD), social anxiety disorder (SAD), or post-traumatic stress disorder (PTSD).  They combined the effects of 67 studies including 5,993 patients. Forty studies included depressive disorders and 27 included anxiety disorders. Most therapies (49 of 78) were characterized as cognitive behavioral therapy (CBT), and the others included interpersonal psychotherapy, psychodynamic therapy, and non-directive counselling. Most patients were seen in individual treatment for 12 to 18 sessions. The most commonly prescribed medications were selective serotonin reuptake inhibitors (SSRI). The overall mean effect size for the difference between psychotherapy and medications was almost zero, indicating no significant difference. Regarding specific disorders and treatments, pharmacotherapy was more effective for dysthymia, but the effect size was small. By contrast, psychotherapy was more effective for OCD, and the effect size was moderately large. SSRI had similar effects to psychotherapy, but non-directive counselling was less effective than pharmacotherapy, though the effect was small.

Practice Implications

This meta analysis by Cuijpers and colleagues found that the differences between psychotherapy and antidepressant medications were non-existent for major depression, panic disorder, and SAD. Although antidepressants were more effective for dysthymia, the difference was small and disappeared when study quality was controlled, and so this finding is not reliable. Psychotherapy was clearly more effective for OCD even after adjusting for study quality and other factors. This is the first meta analysis to show the relative superiority of psychotherapy for OCD, and suggests psychotherapy as a first line treatment. The meta analysis only looked at post treatment results and not at longer term effects. There is evidence from other research showing that antidepressants do not have strong effects after patients stop taking them, whereas psychotherapy’s effects tend to be sustained in the longer term.

Budge, S.L., Moore, J.T., Del Re, A.C., Wampold, B.E., Baardseth, T.P., & Nienhuis, J.B. (2013). The effectiveness of evidence-based treatments for personality disorders when comparing treatment-as-usual and bona fide treatments. Clinical Psychology Review, 33, 1057-1066.

Personality disorders (PD) are more stable and enduring than other mental disorders and are characterized by pervasive, serious, and rigid self-destructive patterns in affect, cognition, interpersonal relations, and impulse control that reduce psychological well-being. PD are associated with higher rates of self injury, suicide, and health care costs. The prevalence of PD in the population ranges from 6% to 13%. The presence of PD in a patient often reduces the effectiveness of psychological treatments for Axis I disorders (e.g., depression, anxiety) that the patient may have. Psychotherapy may be more effective than other interventions, such as pharmacotherapy, for treating PD. In their meta analysis, Budge and colleagues (2013) addressed two questions. First, are manualized evidence-based treatments (EBT) as provided in clinical trials superior to treatment as usual (TAU), presumably as offered in naturalistic settings, for treating PD? Second, are there differences between bona fide treatments (i.e., psychotherapy administered by trained therapists and based on sound psychological theories) for PD? (A note about meta analyses: meta analyses are a statistical method to combine the findings of a large number of studies while accounting for the sample sizes, quality of the studies, and size of the effects. Meta analyses provide us with much more dependable results than any single study could provide). Regarding the first question, 30 studies were included in the meta analysis. Evidence-based treatments included psychodynamic therapies, cognitive behavioral therapies, and dialectical behavior therapy, among others. Overall, EBTs were more effective than TAUs, and the effect was medium sized. The positive effects in favor of EBT over TAU were larger for patients with borderline personality disorder. For the second study comparing bona fide treatments, only 12 studies were found and included in the meta analysis. Only three of the studies indicated that one bona fide therapy was more effective than another. It is also important to note that the average duration of treatment in the EBT studies was 1 year and peaked at 40 sessions.

Practice Implications

As Budge and colleagues (2013) concluded, with sufficient training, supervision, and dose hours, it appears that evidence based treatments (EBT) are more effective than treatments as usual (TAU) for personality disorders (PD). The results of the meta analysis suggested that training in evidence based psychotherapies may be necessary to achieve the best possible outcomes for patients with PD, especially those with borderline personality disorder. Are there differences in between EBTs for PD? The literature on this issue is quite small, so that 12 studies are not enough to make many conclusions. There is previous evidence that psychodynamic therapies and CBT yield very large effects for PD. The pervasiveness and complexity of PD symptoms make it so that effective treatments are necessarily longer term, which is consistent with previous research on this topic.

Handbook of Psychotherapy and Behavior Change: Starting in March 2013 I will review one chapter a month from the Handbook of Psychotherapy and Behavior Change in addition to reviewing psychotherapy research articles. Book chapters have more restrictive copy right rules than journal articles, so I will not provide author email addresses for these chapters. If you are interested, the Handbook table of content and sections of the book can be read on Google Books.

Baldwin, S. & Imel, Z.E. (2013). Therapist effects. In M.E. Lambert (Ed.), Bergin and Garfield’s Handbook of Psychotherapy and Behavior Change, 6^th Edition (pp. 258-297). New York: Wiley.

Does it matter that some therapists are more effective than others? Can less effective therapists be trained to improve their outcomes and relationship quality with patients?  These are important questions not only for our patients’ well-being but also for the long term survival of psychotherapy as a health enterprise. If we do not measure outcomes and help therapists who are less effective, stakeholders (i.e., clients, families, agencies, insurance companies) may stop paying for the services. In the September 2013 blog I discussed a large study that showed that a few therapists were reliably harmful and some therapists were reliably helpful to their patients. That study also reported that most therapists were effective in 5 of 12 problem domains for which their patients sought help. What these findings and the Handbook chapter by Baldwin and Imel (2013) show is that there are significant between-therapist effects (i.e., therapists differed from each other on patient outcomes) and within-therapist effects (i.e., therapist outcomes within their own caseload differed based on the patients’ problems). Baldwin and Imel (2013) reported on their meta analysis in which between-therapist differences accounted for 5% of the outcome variance. That seems small, but it’s not. One study, for example, estimated that for each 100 patients that would be treated, the worst therapist compared to the best therapist would have 6 more patients who deteriorated. I would prefer my loved ones to be seen by the best therapist, even if the difference between best and worst is only 5%. Nevertheless, 95% of the variance in outcomes is within the therapist’s caseload. That is, the patient, other contextual variables, and the therapist-patient relationship are by far the biggest contributors to outcome. As Baldwin and Imel point out, not only are some therapists are more effective for some patients and not others, but also some therapists are better at developing a therapeutic relationship with some patients than with others. Baldwin and Imel reported that, on average, 9% of the variance in the quality of the therapeutic alliance is associated with the therapist – that’s a clinically meaningful effect.

Practice Implications

As Baldwin and Imel (2013) state, ignoring therapist accountability is detrimental to patients and to the mental health field in general. If stakeholders do not see evidence of positive outcomes, then they will withdraw funding, and patients will have even less access to services. Therapists differ in their outcomes, and outcomes also differ within each therapist’s caseload. If a primary goal is to improve therapist performance and patient outcomes, then therapists need to measure outcomes and therapeutic relationship quality. This knowledge about performance with specific patients can help therapists seek continuing education and training to improve outcomes and therapeutic alliances with specific patients for whom the therapist is less effective. This may require continuous outcome monitoring and real-time feedback to therapists regarding their patients’ outcomes (see my September 2013 blog in identifying clients who might deteriorate).

Munder, T., Brütsch, O., Leonhart, R., Gerger, H., & Barth, J. (2013). Researcher allegiance in psychotherapy outcome research: An overview of reviews. Clinical Psychology Review, 33, 501-511.

Although evidence for the efficacy of psychotherapy is largely uncontested, there remains debate about whether one type of treatment is more effective than another. This debate continues despite a recent American Psychological Association (APA) resolution on the equivalent efficacy of most systematic psychotherapy approaches. There are many aspects to this debate (e.g., some treatments are more researched than others and so appear to be better; symptom focused measurements are more sensitive to change and so may favour one treatment over another; some treatments are more amenable to manualization and short term application; etc.). One element of the debate that has received a lot of attention is researcher allegiance. Researcher allegiance refers to researchers preferring one treatment approach over another, and this preference may bias comparative outcome trials in favour of the preferred therapy. Researcher allegiance is measured by assessing primary researchers’ publication history or by their self-declared preference for a particular therapy approach. There exist 30 meta analyses that assessed researcher allegiance since the 1980s. These meta analyses focused on different therapy types, client populations (adults, children), and research designs (randomized trials, naturalistic effectiveness studies). However, some meta analyses have reported contradictory results for the researcher allegiance effect. This could be due to the different foci of the meta analyses (i.e., different treatment approaches, patient populations, age groups, etc.), and also possibly due the allegiance of those conducting the meta analyses. Munder and colleagues (2013) conducted a mega analysis of these meta analyses. As the name implies, a mega analysis aggregates the findings of available meta analyses. Munder and colleagues found a significant moderate effect of researcher allegiance. Researcher allegiance was consistent across patient populations, age groups, outcome measures, type of study design, and year of publication.

Practice Implications

As the APA resolution indicates, psychotherapy is the informed and intentional application of clinical methods and interpersonal stances derived from established psychological principles. Evidence-based practice in psychotherapy is "the integration of the best available research with clinical expertise in the context of patient characteristics, culture and preferences". The results of this mega analysis undermine the claim of some comparative outcome studies that suggest that one evidence-based psychotherapy is more effective than another.

Author email: tmunder@uni-kassel.de

Niemeyer, H., Musch, J., & Pietrowsky, R. (2013). Publication bias in meta-analyses of the efficacy of psychotherapeutic interventions for depression. Journal of Consulting and Clinical Psychology, 81, 58-74.

Meta-analyses are important ways of summarizing effects of medical and psychological interventions by aggregating effect sizes across a large number of studies. (Don’t stop reading, I promise this won’t get too statistical). The aggregated effect size from a meta analysis is more reliable than the findings of any individual study. That is why practice guidelines almost exclusively rely on meta analyses when making practice recommendations (see for example the Resources tab on this web site). However meta analyses are only as good as the data (i.e., studies) that go into them (hence, the old adage: “garbage in, garbage out”). For example, if the studies included in a meta analysis are a biased representation of all studies, then the meta analysis results will be unreliable leading to misleading practice guidelines. One problem that leads to unreliable meta analyses is called publication bias. Publication bias often refers to the tendency of peer reviewed journals not to publish studies with non-significant results (e.g., a study showing a treatment is no better than a control condition). Publication bias may also refer to active suppression of data by researchers or industry. Suppression of research results may occur because an intervention’s effects were not supported by the data, or the intervention was harmful to some study participants. In medical research, publication bias can have dire public health consequences (see this TED Talk). There is lots of evidence that publication bias has lead to a significant over-estimation of the effects of antidepressant medications (see Turner et al (2008) New England Journal of Medicine). Does publication bias exist in psychotherapy research, and if so does this mean that psychotherapy is not as effective as we think? A recent study by Niemeyer and colleagues (2013) addressed this question with the most up to date research and statistical techniques. They collected 31 data sets each of which included 6 or more studies of psychotherapeutic interventions (including published and unpublished studies) for depression. The majority of interventions tested were cognitive behavioral therapy, but interpersonal psychotherapy, and brief psychodynamic therapy were also included. The authors applied sophisticated statistical techniques to assess if publication bias existed. (Briefly, there are ways of assessing if the distribution of effect sizes across data sets fall in a predictable pattern called a “funnel plot” – specific significant deviations from this pattern indicate positive or negative publication bias). Niemeyer and colleagues found minimal evidence of publication bias in published research of psychotherapy for depression. This minimal bias had almost no impact on the size of the effect of psychotherapy for depression.

Practice Implications

This is a very important result indicating that despite a minor tendency toward a selective publication of positive results, the efficacy of all reviewed psychotherapy interventions for depression remained substantial, even after correcting for the publication bias. Niemeyer and colleagues’ findings demonstrate that publication bias alone cannot explain the considerable efficacy of psychotherapy for depression. Psychotherapeutic interventions can still be considered efficacious and recommended for the treatment of depression.

Author email address: helen.niemeyer@hhu.de

Handbook of Psychotherapy and Behavior Change: The Handbook of Psychotherapy and Behavior Change is perhaps the most important compendium of psychotherapy research covering a large number of research areas. The Handbook is updated approximately every 10 years, and the most recent 6^th edition was published in January 2013. In the coming months I will review one chapter a month in addition to commenting on psychotherapy research articles. Book chapters have more restrictive copy right rules about distributing content, so I will not provide author email addresses for these chapters. If you are interested, you can view the table of contents on Amazon.

Lambert, M.J. (2013). The efficacy and effectiveness of psychotherapy. In M.J. Lambert (Ed.) Bergin and Garfield’s handbook of psychotherapy and behaviour change (6^th ed.), pp169-218. Hoboken, N.J.: Wiley.

This comprehensive chapter in the Handbook reviews research on the efficacy and effectiveness of psychotherapy. Lambert’s reviews focus on meta-analyses, which is a way of summarizing effect sizes in a research area. The bottom line is that psychotherapy is effective so that 40% to 60% of clients show substantial benefit in controlled research trials, though the effect is likely smaller in routine practice.  Concurrently, a consistent proportion of adults (5% to 10%) deteriorate during psychotherapy. Patients who receive formal treatment are better off than those who receive no treatment, and bona fide treatments are superior to control conditions that provide only some aspects of effective treatment. When psychotherapy is offered by skilful therapists, on average clients experience appreciable gains and return to normal functioning. Fifty percent of patients achieve clinically significant gains after 8 sessions, and 50% achieve recovery after about 20 sessions of psychotherapy. The effects of psychotherapy tend to be long lasting. For example, only 25% treated depressed patients relapse, whereas 50% of those who receive antidepressants relapse. Research continues to support those therapies that have been rigorously tested, and differences in effectiveness between therapy types (e.g., cognitive behavioural therapy (CBT), psychodynamic, interpersonal, etc.) tend to be small or negligible for many disorders. Cognitive behavioural therapy is still the most tested therapy modality, though other treatments are also accumulating evidence of efficacy. Treatment is likely facilitated by a therapeutic relationship that is characterized by trust, understanding, acceptance, kindness, and warmth. The effect of the therapist providing the therapy is at least as large as the effect of different therapy techniques. That is, some therapists are unusually effective, whereas others may not help the majority of patients who seek their services. Continuous monitoring of outcomes and providing regular feedback to the therapist improves the therapy’s effectiveness.

Practice Implications

Providers and patients can be assured that a broad range of formally defined and tested psychotherapies when provided by skilful therapists are likely to result in appreciable gains in clients including a return to normal functioning. Therapy relationships characterized by trust, understanding, acceptance, and warmth can greatly facilitate change in depression, anxiety, inadequacy, and inner conflicts. When making a decision about which therapy to choose, clients would be wise to consider the therapist as a person at least as much as the type of therapy being offered. Treatment efforts should be based on the best evidence available for treatment types, therapist behaviors, and relationship factors. Routinely monitoring the effects of therapy with each patient will give the therapist ongoing information about their effectiveness and may improve their patients’ outcomes.