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Handbook of Psychotherapy and Behavior Change: Starting in March 2013 I will review one chapter a month from the Handbook of Psychotherapy and Behavior Change in addition to reviewing psychotherapy research articles. Book chapters have more restrictive copy right rules than journal articles, so I will not provide author email addresses for these chapters. If you are interested, the Handbook table of content and sections of the book can be read on Google Books.

Crits-Christoph, P., Connolly Gibbons, M.B., & Mukherjee, D. (2013). Psychotherapy process-outcome research. In M.E. Lambert (Ed.), Bergin and Garfield’s Handbook of Psychotherapy and Behavior Change, 6^th Edition (pp. 298-340). New York: Wiley.

In this section of their chapter in the Handbook, Crits-Christoph and colleagues (2013) review research on: (1) specific techniques of cognitive behavioural therapy (CBT), and (2) change mechanisms of CBT for depression. Research on techniques and mechanisms of change tests the specific or unique effects of a treatment and the rationale for its use. The first issue addresses whether therapist adherence and competence in using CBT techniques produce desired outcomes in patients. CBT techniques include: following an agenda, reviewing homework, asking about specific beliefs, practicing rational responses with patients, and asking patients to keep thought records. Crits-Christoph and colleagues (2013) report that the research findings on the association between using specific CBT techniques and depression outcomes are mixed. The strongest evidence is for concrete techniques such as setting agendas, reviewing homework, and practicing rational responses. However the number of studies that control for prior symptom change and other factors like therapeutic alliance is small, and so the evidence for the specific effects of CBT techniques remains meagre. The second issue addresses whether targeting depressogenic cognitions with CBT results in positive outcomes. Generally, CBT theory argues that the mechanisms by which CBT works is to focus on core depressogenic schemas (i.e., less consciously long held negative beliefs about the self), conscious negative automatic thoughts, and dysfunctional attitudes (i.e., patterns of automatic thoughts) that lead to or maintain depression. Theoretically, addressing these cognitions in CBT should reduce depressive symptoms. Overall, the research shows that both CBT and medication treatment for depression reduce self-reported negative thinking; that is, the effects on negative thinking were not specific to CBT. Few studies show that changes in cognitions precede changes in depressive symptoms, which is a key CBT tenet. The most promising findings suggest that learning compensatory skills (i.e., finding alternative explanations for negative events and thoughts, and problems solving) may be part of the mechanism by which CBT works, but again this mechanism may not be specific to CBT.

Practice Implications

CBT is an effective treatment for depression. CBT theory suggests that the reason for its effectiveness is the use of specific techniques (i.e., reviewing homework, asking for specific beliefs, practicing rational responses with patients, and asking patients to keep thought records) that target the purported causes of depression (i.e., depressogenic shemas, negative thoughts, and dysfunctional attitudes). Currently there is little research evidence that supports the specificity of CBT techniques or that supports the notion that specific changes in cognitions as a result of CBT reduce depression. Nevertheless, in general, concrete techniques (i.e., setting agendas, reviewing homework, and practicing rational responses) are clinically useful for depressed patients, as is learning compensatory skills like problem solving.

Kossowsky, J., Pfaltz, M., Schneider, S., Taeymans, J., Locher, C., & Gaab, J. (2013). The separation anxiety hypothesis of panic disorder: A meta-analysis. American Journal of Psychiatry, 170, 768-781.

The concept of separation anxiety is intimately tied to attachment theory. Problematic early attachments have negative consequences for adults’ ability to experience and internalize positive relationships which help to develop mental capacities to self sooth, tolerate anxiety, and modulate affect. Separation anxiety is the persistent, excessive, and developmentally inappropriate fear of separation from major attachment figures, like parents. It is one of the most frequently diagnosed childhood anxiety disorders, with a lifetime prevalence of 4.1% to 5.1%. If we knew that separation anxiety is truly related to or causes adult psychopathology, then we would have a better understanding of the development of adult mental disorders and greater reason to quickly and aggressively treat childhood separation anxiety. A meta analysis by Kossowsky and colleagues (2013) begins to address this relationship between separation anxiety and adult disorders. They looked at case-control, prospective, and retrospective studies comparing children with and without separation anxiety disorder with regard to future panic disorder, major depressive disorder, any anxiety disorder, and substance use disorders. The meta analysis included 25 studies of 14, 855 participants. Children with separation anxiety were 3.45 times more likely to develop a panic disorder later on; and 5 studies suggested that children with separation anxiety were 2.19 times more likely to develop future anxiety disorders. Childhood separation anxiety disorder did not increase the risk of future depressive disorders or of future substance use disorders. In a subsequent paper, Milrod and colleagues (2014) reviewed the literature on separation anxiety and psychotherapy outcomes of adult anxiety and mood disorders. Separation anxiety is associated with poor response to treatment of adult anxiety and mood disorders possibly because separation anxiety disrupts the therapeutic relationship. Separation anxiety also predicted non-response to antidepressant medications.

Practice Implications

As Kossowsky and colleagues (2013) indicate, it is possible that children suffering from separation anxiety disorder may be hindered early on in developing skills to help cope with anxiety and strong emotions. Nevertheless, the findings draw our attention to the importance of recognizing and treating separation anxiety as early as possible. A few psychological treatment studies show that disorder-specific parent-child cognitive behavioral therapy is successful in treating separation anxiety in children. For adults, poorer treatment response may reflect difficulty forming and maintaining attachments, including the therapeutic relationship. Milrod and colleagues (2014) suggest that psychotherapies that focus on relationships and separation anxiety by using the dyadic therapist-patient relationship to revisit earlier problematic parent-child relationships may benefit adults with separation anxiety.

Budge, S.L., Moore, J.T., Del Re, A.C., Wampold, B.E., Baardseth, T.P., & Nienhuis, J.B. (2013). The effectiveness of evidence-based treatments for personality disorders when comparing treatment-as-usual and bona fide treatments. Clinical Psychology Review, 33, 1057-1066.

Personality disorders (PD) are more stable and enduring than other mental disorders and are characterized by pervasive, serious, and rigid self-destructive patterns in affect, cognition, interpersonal relations, and impulse control that reduce psychological well-being. PD are associated with higher rates of self injury, suicide, and health care costs. The prevalence of PD in the population ranges from 6% to 13%. The presence of PD in a patient often reduces the effectiveness of psychological treatments for Axis I disorders (e.g., depression, anxiety) that the patient may have. Psychotherapy may be more effective than other interventions, such as pharmacotherapy, for treating PD. In their meta analysis, Budge and colleagues (2013) addressed two questions. First, are manualized evidence-based treatments (EBT) as provided in clinical trials superior to treatment as usual (TAU), presumably as offered in naturalistic settings, for treating PD? Second, are there differences between bona fide treatments (i.e., psychotherapy administered by trained therapists and based on sound psychological theories) for PD? (A note about meta analyses: meta analyses are a statistical method to combine the findings of a large number of studies while accounting for the sample sizes, quality of the studies, and size of the effects. Meta analyses provide us with much more dependable results than any single study could provide). Regarding the first question, 30 studies were included in the meta analysis. Evidence-based treatments included psychodynamic therapies, cognitive behavioral therapies, and dialectical behavior therapy, among others. Overall, EBTs were more effective than TAUs, and the effect was medium sized. The positive effects in favor of EBT over TAU were larger for patients with borderline personality disorder. For the second study comparing bona fide treatments, only 12 studies were found and included in the meta analysis. Only three of the studies indicated that one bona fide therapy was more effective than another. It is also important to note that the average duration of treatment in the EBT studies was 1 year and peaked at 40 sessions.

Practice Implications

As Budge and colleagues (2013) concluded, with sufficient training, supervision, and dose hours, it appears that evidence based treatments (EBT) are more effective than treatments as usual (TAU) for personality disorders (PD). The results of the meta analysis suggested that training in evidence based psychotherapies may be necessary to achieve the best possible outcomes for patients with PD, especially those with borderline personality disorder. Are there differences in between EBTs for PD? The literature on this issue is quite small, so that 12 studies are not enough to make many conclusions. There is previous evidence that psychodynamic therapies and CBT yield very large effects for PD. The pervasiveness and complexity of PD symptoms make it so that effective treatments are necessarily longer term, which is consistent with previous research on this topic.

Handbook of Psychotherapy and Behavior Change: Starting in March 2013 I will review one chapter a month from the Handbook of Psychotherapy and Behavior Change in addition to reviewing psychotherapy research articles. Book chapters have more restrictive copy right rules than journal articles, so I will not provide author email addresses for these chapters. If you are interested, the Handbook table of content and sections of the book can be read on Google Books.

Crits-Christoph, P., Connolly Gibbons, M.B., & Mukherjee, D. (2013). Psychotherapy process-outcome research. In M.E. Lambert (Ed.), Bergin and Garfield’s Handbook of Psychotherapy and Behavior Change, 6^th Edition (pp. 298-340). New York: Wiley.

In their chapter in the Handbook, Crits-Christoph and colleagues (2013) review research in which psychotherapy processes are related to patient outcomes. I reported in the July 2013 PPRNet Blog that therapeutic alliance is reliably correlated with treatment outcomes in a variety of disorders and treatment types. Alliance refers to an agreement on tasks and goals of therapy, and the bond between therapist and client. The common assumption is that alliance is a necessary condition that in part causes change in client symptoms. However therapeutic alliance studies tend to be correlational, that is, the studies show a relationship but the study designs do not allow one to say that alliance causes good outcomes. What if the opposite were true; what if early experiences of symptom reduction caused the therapeutic alliance to improve? If that were the case, then alliance would be an artificial and not particularly important aspect of psychotherapy. Crits-Christoph and colleagues (2013) review the literature on this topic. Some studies of cognitive behavioural therapy (CBT), for example, found that prior change in symptoms predicted later therapeutic alliance, but prior alliance did not predict later symptom change. In a more sophisticated study, Crits-Christoph and colleagues (2011) found that previous change in the alliance was related to later change in outcomes, but not vice versa. In the same study, the authors noted that measuring patient alliance at a single early session accounted for only 4.7% of the outcome variance at post treatment, whereas averaging assessments of alliance across 6 early sessions accounted for almost 15% of the outcome variance. In other words, averaging assessments across many sessions produced a more dependable measurement of alliance. Several studies now report a reciprocal relationship between alliance and outcome, indicating that change in alliance and change in outcomes across therapy sessions progress in a mutually reinforcing spiral. That is, early change in alliance causes subsequent change in outcome, which in turn results in further change in alliance, which precipitates more change in symptoms, etc. The review by Crits-Christoph and colleagues (2013) also noted that the importance of alliance seems to be greater for patients with a disorder like depression, compared to anxiety disorders.

Practice Implications

Developing an early alliance with a client is related to treatment outcomes. Measuring alliance repeatedly (not just once) will give the best indicator of the state of the therapeutic relationship. Patients and therapists who have a genuine liking for each other, who agree on how therapy will be conducted and on the goals of therapy will improve the chances that psychotherapy will be successful. Alliance and symptom change may work together throughout therapy so that improvement in one will cause change in the other on an ongoing basis across therapy sessions. Alliance may be particularly important for patients with depressive disorders that are characterized by isolation from others, loneliness, and low self esteem.

Cuijpers, P., Huibers, M., Ebert, D.D., Koole, S.L., & Andersson, G. (2013). How much psychotherapy is needed to treat depression? A metaregression analysis. Journal of Affective Disorders, 147, 1-13.

The question of the number of psychotherapy sessions and of frequency sessions (i.e., number of sessions per week) that are optimal for good outcomes could have implications for how psychotherapy is practiced and how it is reimbursed. In my August 2013 PPRNet Blog, I reported on research that indicated half of patients recover after 21 sessions of psychotherapy. However, that also means that half do not recover in that number of sessions. Many of those who do not recover require another 29 sessions to recover. Research and practice in psychotherapy is largely based on a “one-session-per-week” model. Some researchers, however, have found that an increase in the frequency sessions per week could improve or speed up outcomes. Cuijpers and colleagues (2013) did a meta-regression to assess these questions for short-term psychotherapies for depression. (Meta-regression is a type of meta-analysis in which predictors from many studies are aggregated and their averaged effects on the aggregated outcome are assessed. This produces much more reliable findings than are possible from a single study.) The authors assessed predictors such as the number and frequency of sessions, and they looked at symptom outcomes for depression. The authors found 70 controlled studies that included 5403 patients. More than two-thirds of the studies included CBT as the psychotherapy. Average length of treatment was 11 sessions, and the maximum number of sessions was 24. The number of sessions across studies ranged from .44 to 2 per week, and the average per week was 1. The overall effect size for the treatment was medium sized (g = .59), though the effect became smaller (g = .40) when publication bias was corrected. (Publication bias refers to the likelihood that some less favorable studies or results were not published thus creating an overestimation of the effect of the treatment. See my May 2013 PPRNet Blog). Cuijper and colleagues’ meta-regression showed a small but significant association between greater number of sessions and outcomes for depression; but more importantly, a greater number of sessions per week had a considerably larger positive influence on the effects of psychotherapy for depression.

Practice Implications

The findings from Cuijpers and colleagues (2013) meta-regression are particularly relevant to time limited treatment of depression with CBT. The total number of sessions was less important than the frequency of sessions per week. The results suggest that increasing the intensity or frequency of CBT sessions per week might result in a more efficient therapy and faster relief for patients with depression.

Author email: p.cuijpers@vu.nl

Johnson, S.M, Burgess Moser, M., Beckes, L., Smith, A., Dalgliesh… Coan, J.A. (2013). Soothing the threatened brain: Leveraging contact comfort with emotionally focused therapy. PLoS ONE 8(11): e79314. doi:10.1371/journal.pone.0079314.

Attachment theory argues that a felt sense of connection to others provides a secure base and safe haven, thus increasing one’s tolerance for uncertainty and threat. Improved access to and experience of social resources likely help us regulate negative emotions thus reducing our perception of threat. In a previous study, women in a couple were confronted with a threat (the possibility of a shock to the ankle) while their brain was scanned by functional magnetic resonance imaging (fMRI). These women were either holding the hand of their spouse or the hand of a stranger. Women with the highest quality relationships showed lower threat response in the brain especially while they held the hand of their spouse. Holding the hand of a spouse with whom they had a loving relationship reduced the fear response in these women measured directly in the brain by fMRI. In the study by Johnson and colleagues (2013) the authors wanted to see if improving attachment relationship between couples following Emotionally Focused Couples Therapy (EFT) would result reduced responses to threat measured in the brain. Twenty-three couples completed a course of EFT (23 sessions on average) with experienced therapists. EFT is an evidence based couples treatment that conceptualizes couple distress as caused by unmet attachment needs. When feeling emotionally disconnected, partners in a couple may be anxiously blaming or withdrawing, and this pattern exacerbates relationship distress and threat. EFT focuses on repairing attachment bonds between spouses. In this trial, EFT significantly improved couples’ self reported distress from pre to post therapy. The brain of the female member of the couple was scanned in an fMRI before and after EFT. An electrode was fixed to her ankle, and she was threatened with a mild shock. This procedure took place while she was on her own and while she held her partner’s hand. Threat response was measured by activity in the prefrontal cortex and dorsal anterior cingulate cortex, both of which are associated with processing threat cues and negative affect. EFT resulted in a decrease activity in these areas of the brain from pre to post couples treatment, and these results were especially prominent during hand holding with the partner.

Practice Implications

There is emerging evidence that the effects of psychotherapy like EFT for couples, has a direct impact on the brain that correlates with patients’ self report. In addition, EFT appears to increase the attachment bond between couples and this helps them to regulate their emotions and to moderate their reactions to threat. This study by Johnson and colleagues (2013) also supports some fundamental tenets of attachment theory – that increasing attachment security is possible with psychotherapy and doing so improves affect regulation as measured in the brain. This has broad implications because strong social and attachment bonds help us live longer and enjoy better health.

Author email: jcoan@virginia.edu