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Cuijpers, P., Noma, H., Karyotaki, E.,  Vinkers, C.H., Cipriani, A., & Furukawa, T.A. (2020). A network meta‐analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry, 19, 92-107.

Mental disorders represent a significant health burden worldwide, with over 350 million people affected. Depression is the second leading cause of disease burden. There is ample evidence that psychotherapies and pharmacotherapies are effective in the treatment of depression. There is also evidence for the efficacy of different types of psychotherapy (CBT, IPT, PDT), and for different types of antidepressant medications. Some research suggests that combining psychotherapy and medications is better than either intervention alone, but the evidence is inconclusive. Existing meta analyses only compare two existing treatments directly to each other at a time: psychotherapy vs medications, psychotherapy vs combined treatments, medications vs combined treatments. In this meta-analysis, Cuijpers and colleagues use a method called “network meta-analysis” to study the relative impact of medications, psychotherapy, or their combination. Network meta-analysis is controversial because it relies on indirect comparisons to estimate effects. For example, let’s say one study compared medications (A) to psychotherapy (B), and another study compared medication (A) to combination treatment (C), then a network meta-analysis would estimate the effects of psychotherapy vs combination treatment by using the transitive principle (if A = B, and B = C, then A = C). This logic relies on everything being equivalent across studies. However, in treatment trials one cannot assume that the different studies comparing A, B, and C are equivalent in terms of quality and bias (in fact, we know they are not). In any case, Cuijpers and colleagues found that combined treatment was superior to ei­ther psychotherapy alone or pharmacotherapy alone in terms of standardized effect sizes (0.30, 95% CI: 0.14-0.45 and 0.33, 95% CI: 0.20-0.47). No significant difference was found between psychotherapy alone and pharmacotherapy alone (0.04, 95% CI: –0.09 to 0.16). Interestingly, acceptability (defined as lower patient drop-out rate and better patient adherence to the treatment) was significantly better for combined treatment compared with pharmacotherapy (RR=1.23, 95% CI:

1.05-1.45), as well as for psychotherapy compared with pharmacotherapy (RR=1.17, 95% CI: 1.02-1.32). In other words, pharmacotherapy alone was less acceptable to patients than another treatment approach that included psychotherapy.

Practice Implications

This network meta-analysis by a renowned researcher and in a prestigious journal adds to the controversy around the relative efficacy of psychotherapy vs medications vs their combination. What is clear is that patients find medication alone to be less acceptable as a treatment option, and previous research shows that patients are 4 times more likely to prefer psychotherapy over medications. Unfortunately, most people with depression receive medications without psychotherapy.

Courtois, C. A. & Brown, L. S. (2019). Guideline orthodoxy and resulting limitations of the American Psychological Association’s Clinical Practice Guideline for the Treatment of PTSD in Adults. Psychotherapy, 56(3), 329-339.

Recently the American Psychological Association (APA) published clinical practice guidelines for the treatment of post-traumatic stress disorder (PTSD). The reaction from the clinical community that treats those with PTSD, client groups, and from many academic and research quarters was swift and negative. APA received almost 900 comments in their public consultations from many who felt the document was overly prescriptive, overly symptom-focused, and narrow in its recommendations. In this interesting inside look at the process, the Chair of the PTSD Practice Guidelines Committee (Christine Courtois) and a senior member of the Committee (Laura Brown) wrote a scathing commentary of the process imposed on them by APA that constrained the Committee’s access to information which affected their decisions. The Committee was bound by APA’s use of the Institute of Medicine (IOM) rules for developing practice guidelines. In other words, a psychological organization (APA) used a biomedical model to define what is relevant research, how to define treatment, what is an appropriate outcome, and how to decide on recommendations. As a result, the APA Committee reached several conclusions/decisions that were biased or premature. First, they defined PTSD only by its symptom presentation and not for the complex disorder that it is. In other words, PTSD was viewed almost exclusively from within a framework that defined it as only a fear-based response to a stressor. Such an approach downplays any developmental or attachment-related factors in the genesis or maintenance of PTSD. Second, the Committee was instructed to ignore a vast array of research on therapist factors, relationship factors, and client factors in psychotherapy. This runs counter to many clinicians’ views that one cannot engage in technical interventions related to PTSD symptoms without the patient experiencing a heightened sense of security in their relationship with the therapist. This also meant that the Committee largely ignored cultural and diversity factors. Third, the treatment recommendations focused on time-limited exposure-based interventions – which is a natural outcome of the first two decisions (i.e., seeing PTSD as only fear-based, ignoring issues of development, and ignoring relational factors in the treatment context). The authors were also disappointed that the APA ignored its own policy on evidence-based practice that puts equal weight on research, clinician expertise, and client factors when making clinical decisions. In the end the authors clearly were not confident in the narrow focus of the Clinical Practice Guideline, and they were concerned that clinicians, researchers, policy makers, and third party funders could misuse the Guideline to limit research, theory, and funding.

Practice Implications

In this extraordinary piece, the Chair and a senior committee member of the PTSD Practice Guideline Committee were highly critical of the process and outcome of APA’s effort to develop clinical practice guidelines for PTSD. The authors did not diminish the importance of exposure-based interventions for PTSD, however they did argue that these interventions must be offered only after clinicians take a sufficient amount of time to create a clinical context characterized by clients experiencing heightened safety in the therapeutic relationship, and to into account client preferences and culture. Further, clinicians should be highly sensitive to attachment-related insecurities and developmental traumas that may lengthen the treatment and that may have a complicating impact on the therapeutic relationship.

Norcross, J. C., & Wampold, B. E. (2019). Relationships and responsiveness in the psychological treatment of trauma: The tragedy of the APA Clinical Practice Guideline. Psychotherapy, 56(3), 391-399.

The American Psychological Association’s (APA) Clinical Practice Guideline for Posttraumatic Stress Disorder in Adults published in 2017 was met with a great deal of concern and criticism by the community of scholars and practitioners working with patients with PTSD. A key concern was that the APA used a biomedical model and not a psychological or contextual model in guiding their understanding of PTSD, their approach to what constitutes evidence, and to decisions about recommended treatments. In particular, the biomedical approach focuses almost exclusively on treatment methods, and down-plays the context of treatment (i.e., the relationship, patient factors, and therapist responsiveness). In this critique, Norcross and Wampold highlight the flaws in the APA Clinical Practice Guideline for PTSD, and the authors focus specifically on those variables that are known to predict patient outcomes but that were ignored by the Guideline. Norcross and Wampold highlighted that there exists numerous meta analyses that demonstrate that all bona fide psychotherapies work about equally well for trauma, and that the particular treatment method has little impact on PTSD outcomes. Yet, the restrictive review process undertaken by APA all but ignored this well-established finding. Also ignored was the research on the importance of the therapeutic relationship in the treatment of trauma. One review outlined nineteen studies that found that the therapeutic alliance was associated with or predicted reduction in PTSD symptoms. This is consistent with the general psychotherapy research literature, in which the alliance is the most researched and most reliable factor related to patient outcomes. Also missing from the PTSD Guideline was reference to a large body of research on therapist responsiveness to patient characteristics. Patients are more likely to improve if their therapists can adapt to the patient’s coping style, culture, preferences, level of resistance, and stage of change. In one study of cognitive-processing therapy (CPT; a treatment recommended by the APA Guideline), there were substantial differences between therapists in their patient’s PTSD symptom outcomes. That is, some therapists reliably were more effective than others, even though all therapists were trained in and supervised in providing the same manualized evidence-based treatment. Among the identified skills of the most effective CPT therapists were: a flexible interpersonal style, and an ability to develop and maintain a good therapeutic alliance across patients.

Practice Implications

There is growing consensus that the APA Clinical Practice Guideline for PTSD are based on dubious methodology and are of limited use to therapists and their patients with PTSD. Psychotherapists should practice a bona-fide therapy for PTSD, but should do so by taking into account the treatment context. In other words, more effective therapists are good at developing, maintaining, and repairing the therapeutic alliance across a range of patients. Effective therapists can also respond and adapt to patient characteristics such as level of resistance, coping style, culture, and stage of change. And so, even when providing a treatment based on the APA Guideline, therapists should nurture trust in the therapeutic relationship and be adaptive to their patients’ characteristics.

Merz, J., Schwarzer, G., & Gerger, H. (2019). Comparative efficacy and acceptability of pharmacological, psychotherapeutic, and combination treatments in adults with posttraumatic stress disorder: A network meta-analysis. JAMA Psychiatry, 76, 904-91.

Posttraumatic stress disorder (PTSD) is a highly debilitating disorder characterized by re-experiencing trauma, avoidance of situations related to the trauma, negative mood and cognitions, and hyperarousal. The lifetime prevalence of PTSD in the population is about 8%, and PTSD is associated with a great deal of medical problems, and social and economic burden. Difference between a variety of psychological treatment approaches for PTSD are small and not statistically significant. Some treatment guidelines tend to recommend both psychotherapy and pharmacotherapy to treat PTSD, but other guidelines indicate only psychotherapy as the first-line treatment. Merz and colleagues conducted a meta-analysis to examine comparative outcomes and acceptability of psychotherapy and pharmacotherapy and their combination in adults with PTSD. The authors focused on randomized controlled trials because these designs tend to produce the most reliable evidence. The authors identified 12 published studies with a total of 922 participants. Six of the studies included data on long term outcomes. The meta-analytic procedures that the authors used in this study included network meta-analyses (which some have argued may produce unreliable results) and direct comparison meta-analysis (which is more reliable, but resulted in fewer studies being included here). I report in this blog only results that were consistent between the network and direct comparison analyses. Pharmacological and psychotherapeutic treatments and their combinations were not significantly different in their effectiveness immediately post-treatment. However, at long-term follow-up psychotherapy was significantly more beneficial than pharmacotherapy (SMD, −0.63; 95% CI, −1.18 to −0.09). Combined psychotherapy plus pharmacotherapy was not significantly more effective that pharmacotherapy alone (SMD, −1.02; 95% CI, −2.77 to 0.72), and combined treatment was not more effective that psychotherapy alone (SMD, 0.06; 95% CI, −0.31 to 0.42). There were also no statistically significant differences between psychotherapy, pharmacotherapy, or their combination in the acceptability of treatments to participants as defined by differing rates of dropping out from the studies.

Practice Implications

This meta-analysis of a small number of studies suggests that psychotherapy produces better long-term outcomes than pharmacotherapy for PTSD. There is also a suggestion that combining psychotherapy and pharmacotherapy does not improve outcomes compared to either treatment alone. This research area seems to be new and not well developed, but so far, the results seem to favor psychotherapy for longer term outcomes. These findings are similar to those from a larger meta-analysis for depression. In that study, the authors suggested that the long-term benefit of psychotherapy was due to participants learning coping and interpersonal skills that were not gained from receiving pharmacological intervention alone.

Sakaluk, J. K., Williams, A. J., Kilshaw, R. E., & Rhyner, K. T. (2019). Evaluating the evidential value of empirically supported psychological treatments (ESTs): A meta-scientific review. Journal of Abnormal Psychology, 128(6), 500-509.

In the 1990s the Clinical Division of the American Psychological Association commissioned a Task Force to identify “Empirically Supported Treatments” (EST). The Task Force decided that psychotherapies that repeatedly showed statistically significant improvements over no treatment, placebos, or another treatment would be designated as “Strongly” supported. They also designated some treatments as “Modestly” supported or with “Controversial” support. The EST movement continues to have a great impact on the practice, research, and funding of psychotherapy. Time-limited, diagnosis-focused therapies, tested in randomized controlled trials became the “gold standard”. Clinicians are expected to practice these ESTs, research agencies focus funding on these models, and some governments and insurance companies provide reimbursements only for these types of therapy. The Empirically Supported Treatments (EST) movement redefined the practice of psychotherapy as short-term, symptom-focused, technically-oriented, and mostly cognitive-behavioral. In this meta-scientific review Sakaluk and colleagues asked: how good is the evidence for the ESTs? The authors were particularly concerned with the quality of the studies from a methodological and statistical point of view: how likely was it that these findings could be replicated, or how reliable were the findings? The good news is that there were few instances (about 10%) of research supporting ESTs in which researchers mis-reported the statistics (i.e., error in the reporting of statistical findings). This is quite a bit lower than previously identified mis-reporting rates (about 50%) in psychological research in general. However, only about 19% of ESTs were supported consistently by high quality studies. Over half of ESTs were supported consistently by poor quality studies. Most of the studies supporting ESTs were not sufficiently powered to detect differences between treatments or conditions. That is, often the sample sizes of patients in the studies were too small, and so the significant results were not likely reliable or perhaps not plausible. Also, those therapies that the EST list defined as having “Strong” support were not backed by more higher quality research compared to therapies considered to have “Moderate” support. In other words, the decision to designate treatments as “Strongly” or “Moderately” supported appears to have almost no relationship with the quality of the research.

Practice Implications

Embedded in this dense methodological paper are some troubling findings and important practice implications. The authors suggested that there are a number treatments on the EST list that have dubious research support because the studies of those treatments may not stand up to replication (a critical test in scientific research). It is not clear that ESTs are any more effective than other bona-fide psychotherapies that are not on the list. (Bona-fide psychotherapies are those that are based on a psychological theory, delivered by trained therapists, and in which the patient and therapist develop a relationship). The findings question whether dissemination of and training in ESTs to the exclusion of other psychotherapies can be justified given the quality of the evidence. In other words, it is possible that other bona-fide psychotherapies that are not on the EST list may be just as effective. This does not imply that psychotherapy is not effective or that anything goes when it comes to the practice of psychotherapy. Evidence-based practice in psychotherapy should guide psychotherapists’ clinical choices. However, the EST list is not the final word on what constitutes “evidence-based” practice in psychotherapy, or on what treatments should be researched and funded.

Wampold, B.E., Flückiger, C., Del Re, A.C., Yulish, N.E., Frost, N.D., …Hilsenroth, M. (2017) In pursuit of truth: A critical examination of meta-analyses of cognitive behavior therapy, Psychotherapy Research, 27, 14-32.

The vast majority of meta-analyses of studies that compare different brands of psychotherapy for any particular disorder indicate that differences between treatments are quite small and clinically trivial. Meta-analyses are an important way of aggregating effect sizes across studies and of providing reliable estimates of the state of a research field. But meta-analyses are not perfect - they rely on judgements made by the researchers that may bias findings. Despite a large body of evidence to the contrary, three meta-analyses in particular have purported to demonstrate that cognitive-behavioral therapy (CBT) is superior to other therapies for some specific disorders. In this paper, Wampold and colleagues critically review these three meta analyses to see if in fact CBT is superior to other psychotherapies. A meta-analysis by Tolin that reported that CBT was more efficacious than other therapies for anxiety and depression was surprising given that it contradicted 5 previous meta-analyses. It turns out that Tolin misclassified some treatments as CBT (including eye movement desensitization and reprocessing [EMDR] and present-centred therapy [PCT]). Further, Tolin made a critical computational error with one of the studies that when corrected wiped out any superiority for CBT. A second meta-analysis by Marcus and colleagues reported small differences in favor of CBT for primary (i.e., target symptoms) outcomes at post-treatment but not at follow up. Wampold and colleagues reported that the small difference at post-treatment was unduly affected by one study in the meta-analysis that showed unusually large effect in favor of CBT (i.e., the study was likely unreliable because its results were so much out of line with all other studies). Further, the purported superiority of CBT disappeared in the longer term. Finally, a meta-analysis by Mayo-Wilson and colleagues published in the prestigious journal Lancet Psychiatry used a network meta-analysis to compare treatments, and reported that CBT was more effective than other psychotherapies. Network meta-analysis relies heavily on indirect comparisons rather than including only studies that directly compared two therapy modalities. For example, if there are only a few studies that compare treatment A to treatment B (AB), one could look at studies of treatment A versus treatment C (AC), and studies of treatment B versus treatment C (BC), and then use the transitive property (remember high school math?) to estimate the effect of AB indirectly from the studies of AC and BC. It turns out that this practice in the context of meta-analysis is unreliable and can grossly over-estimate differences between treatments.

Practice Implication

The vast majority of meta-analyses show that bona-fide psychotherapies are effective, and one therapeutic orientation does not seem to be superior to another. The three meta-analyses that run counter to this conclusion are deeply flawed. To claim that one treatment is more effective than another will limit patients’ access to other treatments. This is concerning, since most time-limited treatments result in about half of patients recovering from their mental health problems. And so many patients and their therapists need more therapeutic options to draw upon. Falsely claiming that one treatment is more effective than others may lead insurance companies and government policy makers to make erroneous decisions to fund only one type of therapy.