Blog
The Psychotherapy Practice Research Network (PPRNet) blog began in 2013 in response to psychotherapy clinicians, researchers, and educators who expressed interest in receiving regular information about current practice-oriented psychotherapy research. It offers a monthly summary of two or three published psychotherapy research articles. Each summary is authored by Dr. Tasca and highlights practice implications of selected articles. Past blogs are available in the archives. This content is only available in English.
This month...
…I blog about content from the updated edition of the Handbook of Psychotherapy and Behavior Change, published in 2021: the effectiveness of psychotherapist training, the therapist effect, and therapist responsiveness to patient interpersonal behaviours.
Type of Research
Topics
- ALL Topics (clear)
- Adherance
- Alliance and Therapeutic Relationship
- Anxiety Disorders
- Attachment
- Attendance, Attrition, and Drop-Out
- Client Factors
- Client Preferences
- Cognitive Therapy (CT) and Cognitive-Behavioural Therapy (CBT)
- Combination Therapy
- Common Factors
- Cost-effectiveness
- Depression and Depressive Symptoms
- Efficacy of Treatments
- Empathy
- Feedback and Progress Monitoring
- Group Psychotherapy
- Illness and Medical Comorbidities
- Interpersonal Psychotherapy (IPT)
- Long-term Outcomes
- Medications/Pharmacotherapy
- Miscellaneous
- Neuroscience and Brain
- Outcomes and Deterioration
- Personality Disorders
- Placebo Effect
- Practice-Based Research and Practice Research Networks
- Psychodynamic Therapy (PDT)
- Resistance and Reactance
- Self-Reflection and Awareness
- Suicide and Crisis Intervention
- Termination
- Therapist Factors
- Training
- Transference and Countertransference
- Trauma and/or PTSD
- Treatment Length and Frequency
March 2015
Interpersonal Psychotherapy and Cognitive Therapy for Depression
Lemmens, L.H.J.M., Arntz, A., Peeters, F., Hollon, S.D., Roefs, A., & Huibers, M.J.H. (2015). Clinical effectiveness of cognitive therapy v. interpersonal psychotherapy for depression: Results of a randomized controlled trial. Psychological Medicine, doi:10.1017/S0033291715000033
Generally, I prefer to report on meta analyses rather than individual studies mainly because findings from meta analyses are based on a larger number of studies and so are more reliable (see my November, 2013 blog). However, this study by Lemmens and colleagues represents a large clinical trial of 182 depressed patients who were randomized to cognitive therapy (CT), interpersonal psychotherapy (IPT), or a no-treatment control condition. The size of the trial provided the study with enough statistical power to test a hypothesis of non-inferiority of treatments. (A statistical note: A study finding of “non-inferiority” between treatments is sometimes unreliable because it is easier to detect such a finding with a small or poorly designed study. Studies with larger sample sizes provide greater statistical power, which in part makes a non-inferiority finding more reliable). A previous meta analysis showed both CT and IPT to be equally effective interventions for major depression. However, none of the studies in that meta analysis had sufficiently large sample sizes to reliably detect non-inferiority of interventions, none reported outcomes after post-treatment, and none of the studies used a no-treatment comparison condition. In their study, Lemmens and colleagues provided 16 to 20 sessions of individual therapy (45 minutes in length) to participants who met criteria for major depressive disorder. CT was based on Beck’s model and focused on identifying and altering cognitions, schemas, and attitudes associated with negative affect. IPT seeks to understand the social and interpersonal context of a patient’s depressive symptoms, and helps the patient to solve the interpersonal problem or change their relation to the problem, which may result in a resolution of the depressive symptoms. The study by Lemmens and colleagues was well designed in which: patients were randomized to conditions (CT, IPT, wait-list), 10 licensed therapists were expertly trained (5 CT therapists, 5 IPT therapists), and the therapies were competently delivered. Depressive symptoms significantly decreased for patients in both CT and IPT conditions with large effects, and these findings remained stable to 5 months post treatment. There were no differences between CT and IPT at post treatments and follow up, and both treatments were more effective than the waitlist control condition. Half of the sample had clinical improvements in symptoms, and 37% of patients were without depressive symptoms at 1 year follow up.
Practice Implications
CT and IPT did not differ in the treatment of depression in the short (post-treatment) and long term (follow up). The study does not address why two very different treatments led to similar positive outcomes. The authors suggest two possible reasons: (1) different specific treatment pathways led to similar results, or (2) change was driven by factors common to both treatments like motivation and therapeutic alliance.
February 2015
Common Factors in Psychotherapy: What Are They and Why Are They Important?
Laska, K. M., Gurman, A. S., & Wampold, B. E. (2014). Expanding the lens of evidence-based practice in psychotherapy: A common factors perspective. Psychotherapy, 51(4), 467-481.
In this wide ranging review of the Common Factors (CF) perspective in psychotherapy, Laska and colleagues tackle the complex issues of defining CF and describing the evidence. The authors argue that CF in psychotherapy are not a vague set of ideas that fit under the label of “non-specific factors” or “relationship factors”. They also state that there is an unnecessary dichotomy between the concepts of empirically supported treatments (EST) and CF. In EST, specific and brief manualized therapies for specific disorders are tested in highly controlled randomized trials. ESTs purport that efficacious psychotherapies contain specific techniques based on an articulated theory of the disorder, and a specific mechanism of change for that disorder (e.g., depression is partly caused by depressogenic beliefs and so CBT for depression specifically targets cognitive distortions). There are published lists of ESTs for many disorders. However, Laska and colleagues argue that there is little evidence of the specificity of these treatments. For example, in dismantling studies an intervention like CBT for depression is compared to a dismantled version that removes an “active ingredient” [e.g., by providing only behavioral activation as an intervention], with little difference in patient outcomes between the full and dismantled versions. Further, for a number of disorders, several therapies based on very different theories of the disorder and of change are equally effective. In contrast to the EST approach, Laska and colleagues describe the CF approach which focuses on factors that are necessary and sufficient for patient change across psychotherapies, such as: (1) an emotional bond between client and therapist, (2) a healing setting for therapy, (3) a therapist who provides a theoretically and culturally relevant explanation for emotional distress, (4) an adaptive explanation that is acceptable to clients, and (5) procedures that lead clients to do something that is positive and helpful. Nevertheless, CF does not provide therapists with a license to do whatever they want without considering the evidence of a therapy’s efficacy. Rather CF does encourage therapists to make use of specific factors found in ESTs and to practice with a purpose. In support of the importance of CF, Laska and colleagues review the evidence from a number of meta analyses that show that CF (i.e., alliance, empathy, collaboration, positive regard, genuineness, therapist effects) each account for 5% to 11.5% of patient outcomes. These are moderate effects. Specific ingredients of psychotherapies or differences between ESTs account for 0% to 1% of patient outcomes, which represent small effects.
Practice Implications
An excessive focus or reliance on empirically supported therapies (EST) may unnecessarily limit what the profession and funders consider to be evidence-based practice. A common factors (CF) approach provides scientific evidence for effective therapeutic practices that are necessary in addition to the specific treatments found in lists of ESTs. To be effective, therapists should be able to: (1) develop a therapeutic alliance and repair ruptures to the alliance, (2) provide a safe context for the therapy, (3) be able to communicate sound psychological theory for the client’s distress based on evidence, (4) suggest a course of action that is based on evidence, and (5) conduct therapy based on established theories of distress and healing. Laska and colleagues argue that systematic patient progress monitoring and ongoing monitoring of the therapeutic alliance may be an effective method of quality improvement of therapists’ outcomes. Progress monitoring may provide therapists with information about areas for continuing education to improve their patients’ outcomes.
Evidence for Psychotherapy of PTSD in Adults Who Experienced Childhood Abuse
Ehring, T., Welboren, R., Morina, N., Wicherts, J.M., Freitag, J., & Emmelkamp, P.M.G (2014). Meta-analysis of psychological treatments for posttraumatic stress disorder in adult survivors of childhood abuse. Clinical Psychology Review, 34, 645-657.
Post-traumatic stress disorder (PTSD) occurs at a very high frequency among those who experienced childhood physical and/or sexual abuse. As adults these individuals often request mental health services. Previous meta analyses of psychotherapies for PTSD have combined samples of those with PTSD due to childhood maltreatment and those due to trauma in adulthood. This meta analysis by Ehring and colleagues is the first specifically to look at treatment of PTSD in those with childhood abuse. Some argue that PTSD due to childhood abuse is different because of the high level of complex symptoms like emotion regulation problems, impulsivity, depression, dissociation, substance abuse, and others. And so treatments for PTSD related to childhood abuse may require different characteristics and may have different outcomes. Further, there is a long standing debate about whether trauma-focused treatments are appropriate for those with PTSD who have high levels of complex symptoms. There is concern for example that the focus on trauma memories may exacerbate symptoms like dissociation. Previous reviews showed that treatments targeting the trauma memory (i.e., focus on processing the memory and its meaning) had the largest effect on PTSD outcomes. This is likely because of the impact that memory processes (i.e., re-accessing memories, maladaptive attributions of memories) have on the maintenance of the disorder. Would these large treatment effects also be found in PTSD that resulted specifically from childhood abuse? (A note about meta analyses: meta analyses are the best way to synthesize a research area because this method combines the effect sizes from multiple studies into a single effect size. The findings of meta analyses are much more reliable than findings from any single study. See my November 2013 blog). Ehrling and colleagues conducted a meta analysis of 16 studies that included over 1200 participants with PTSD due to childhood abuse. Treatments included: trauma-focused cognitive behavioral therapy (CBT), non-trauma-focused CBT, eye movement desensitization and reprocessing (EMDR), and others. Psychological interventions were effective for PTSD related to childhood abuse, and the effects were large for both PTSD symptom severity and for other symptoms (i.e., depression, anxiety, dissociation). Psychological interventions were more effective that control conditions (i.e., wait lists or treatments as usual), and these effects were moderate. Effects remained large or moderate well into post-treatment follow-ups. Trauma focused treatments were more effective than non-trauma-focused treatments, and individual interventions were more effective than group-based interventions.
Practice Implications
Psychological interventions for PTSD in adults who experienced childhood abuse are effective in reducing symptom severity with moderate to large effects. Other symptoms like anxiety, depression, and dissociation also showed large positive changes in these individuals. Research shows that trauma-focused treatments are under-used in routine practice. This may be due to the concern that trauma-focused treatments may not be safe in some individuals with complex symptoms. Trauma-focused treatments may lead to higher effects than non-trauma focused treatments, indicating the potential importance of processing the trauma memory.
January 2015
Psychological Therapy After a Suicide Attempt: A Nationwide Study
Erlangsen, A., Lind, B. D., Stuart, E. A., Qin, P., Stenager, E., Larsen, K. J., ... & Nordentoft, M. (2014). Short-term and long-term effects of psychosocial therapy for people after deliberate self-harm: A register-based, nationwide multicentre study using propensity score matching. The Lancet Psychiatry. Early Online Publication: doi:10.1016/S2215-0366(14)00083-2.
Between 9 million and 35 million suicide attempts occur yearly in the world, and suicide accounts for over 800,000 deaths every year worldwide. Suicide attempts are associated with future attempts and with mortality. Within the first year, 16% of people attempt suicide again. Despite the occurrence of suicide attempts and its effects, there has been inconclusive evidence of the effectiveness of interventions to reduce future attempts and death. That is why this Danish nationwide study by Erlangsen is so important. Another impressive aspect of this study is its size and scope. Since 1992, psychological therapies have been offered to people at risk of suicide in specialized clinics throughout Denmark. The aim of Erlangsen and colleagues’ study was to assess if those who received these psychological interventions had a reduced risk of suicidal behavior and mortality compared to people who did not receive the interventions. The authors collected data from 1992 to 2010 from Danish national health registries. This procedure was possible in Denmark because the health system is nationally coordinated and each individual has a traceable national health ID. In order to be included in the study, those who were offered specialized psychological interventions had to receive at least one session of treatment. Therapy included cognitive behavioral therapy, problem solving therapy, dialectical behavior therapy, psychodynamic therapy, systemic therapy and others. The interventions consisted of up to 8 to 10 individual outpatient sessions. The comparison group received “standard care” that consisted of admission to hospital, referral to a general practitioner, or discharge with no referral. The primary outcomes were: repeated self-harm, death by suicide, and death by any other cause. Of the people receiving psychotherapy, 5,678 had useable data. The “standard care” sample was much larger and consisted of 58,281 individuals who were matched to the psychological intervention group on many variables including sex, age, education, antidepressant medications, and psychiatric diagnosis. For those receiving psychotherapy, the rate of repeated suicide attempts in the first year was 6.7% and 15.5% at 10 years. For those receiving standard care, rate of repeated suicide attempts in the first year was 9.0% and 18.4% at 10 years. The odds of another suicide attempt one year post treatment was 73% lower among those receiving psychotherapy. Death by any other cause at the 10 year mark was also significantly lower in the psychological therapy group (5.3%) versus the no-therapy group (7.9%). The authors estimated that over the 20 year span of their data, psychological therapy: prevented repeated suicide attempts in 145 people, prevented deaths by any other cause in 153 people, and prevented 30 suicide deaths. Psychosocial interventions were associated with fewer repeated suicide attempts in women but not in men, and adolescents and young adults benefited most from psychological therapies.
Practice Implications
This is the largest long term follow up study ever of psychological interventions after a suicide attempt. Psychotherapy was associated with reduced risk of self-harm and mortality in the short and long term. This was especially true for women and in adolescents and young adults. Those receiving psychotherapy might have been a select group resulting in biased results. However, the extensive matching of the psychotherapy group to the no-therapy control group reduced the likelihood that factors other than psychotherapy influenced the findings. The study indicates strong support for providing psychological interventions to people at risk of suicide.
Rate of Drop-Out From Psychotherapy Differs by Treatment Type, but Only for Some Disorders
Swift, J. K., & Greenberg, R. P. (2014). A treatment by disorder meta-analysis of dropout from psychotherapy. Journal of Psychotherapy Integration, 24(3), 193-207.
In one of my first PPRNet Blogs I reported on a meta analysis by Swift and Greenberg (2012) in which they found that almost 1 in 5 patients in clinical trials dropped out of therapy. There were no differences between therapeutic orientations in the drop out rates. However, the authors did report that those with eating disorders (23.9%) and personality disorders (25.6%) dropped out at a higher rate than other disorders. Premature termination from therapy is an important problem in that those who drop out are less satisfied and have poorer outcomes than treatment completers. In this follow up to their meta analysis, Swift and Greenberg ask the interesting question of whether premature termination differs across therapy orientations for any of the specific disorders. They compared the drop out rates of different treatment approaches for each of 12 separate disorders. The studies defined drop out in various ways, including: unilateral termination, not attending a set number of sessions, not achieving clinically significant change, etc. Treatment orientations, included: behavior therapy, cognitive–behavioral therapies, dialectical behavior therapy (DBT), psychodynamic psychotherapies, solution-focused therapy, interpersonal psychotherapy, humanistic/existential/supportive psychotherapies, and integrative approaches. Primary diagnoses included: depression, eating disorders, borderline personality disorder, other personality disorder, somatoform disorder, bereavement, obsessive compulsive disorder, generalized anxiety disorder, panic disorder, post-traumatic stress disorder (PTSD), psychotic disorders, and social phobia. The authors conducted 12 meta analyses, one for each disorder to compare the therapy approaches. Overall, they included 587 studies. There were no differences in drop out rates among therapy approaches for 9 of the 12 disorders. For depression, integrative therapy had significantly lower drop out rates than other approaches (10.9% vs 19.2%), and for PTSD integrative therapy also had the lowest drop out rate compared to other treatments (8.8% vs 21.0%). Also, for PTSD, exposure based interventions had the highest drop out rates (up to 28.5%). For eating disorders, DBT had the lowest drop out rates compared to other approaches (5.9% vs 24.2%), but this was largely explained by older patient samples and shorter duration of treatment in DBT.
Practice Implications
There were no differences between treatments in drop out rates for 9 of 12 disorders. Swift and Greenberg argued that for these disorders, other factors (e.g., therapeutic alliance, client expectations) rather than specific techniques were enough to keep clients in therapy. For depression and PTSD, integrative treatments resulted in the lowest drop out rates. This suggests that therapists might consider incorporating techniques from other orientations that increase the acceptability of therapy for their clients with depression and PTSD. Use of exposure based interventions for PTSD may require a significant amount of work to prepare clients in order to reduce higher drop out rates.
December 2014
Does Cognitive Therapy Have an Enduring Effect Superior to Keeping Patients on Medication?
Cuijpers, P., Hollon, S. D., van Straten, A., Bockting, C., Berking, M., & Andersson, G. (2013). Does cognitive behaviour therapy have an enduring effect that is superior to keeping patients on continuation pharmacotherapy? A meta-analysis. BMJ open, 3(4).
In another in a series of meta analyses by this primarily Dutch group, Cuijpers and colleagues tackle the question of whether the longer term effects of cognitive behavioral therapy (CBT; a short time-limited treatment for depression) outweighs the long term effects of continuation on anti depression medications. CBT is considered an efficacious treatment for depression (see my June 2014 Blog). CBT also has comparable effects as antidepressant medications, but CBT tends to have lower rates of treatment drop outs. What is not clear is whether short term CBT leads to lasting change that is comparable to long term use of medications for depression. One could argue for example, that short term CBT or other comparable psychological interventions teaches patients skills or changes psychological functioning such that future recurrences of depression are less likely. That is, psychological interventions may cause changes that eventually will prevent relapse. Pharmacotherapy on the other hand, may not result in psychological change or acquisition of new skills to forestall a relapse. In fact, patients with chronic depression tend to be kept on medications indefinitely, and patients who recently remit (i.e., no longer have symptoms of depression) are typically kept on pharmacotherapy for another 6 to 12 months to reduce the risk of recurrence. Information about the relative longer term effects of short term treatment with a psychological intervention like CBT versus longer term maintenance on pharmacotherapy can help practitioners and patients decide on the best course of action depending on patient preferences. Cuijpers and colleagues asked: is short term CBT without continuation of treatment as effective as short term treatment of pharmacotherapy with and without long term continuation? They conducted a meta analysis in which the effects of short term CBT were compared to pharmacotherapy in adults diagnosed with depression across follow up periods of 6 to 18 months. Nine studies representing 506 patients were included in the meta analysis. There was a non-significant trend showing that short term CBT outperformed continuation pharmacotherapy at one-year post treatment. On the other hand, CBT resulted in better long term outcomes compared to pharmacotherapy that was discontinued at post treatment. The odds of dropping out of treatment were significantly higher for those receiving pharmacotherapy compared to CBT. There were no differences in any of the findings for type of antidepressant medications.
Practice Implications
The findings reaffirm CBT as a first-line treatment of depressive disorders. It also suggests that equally effective other psychological treatments may also have similar enduring effects compared to pharmacotherapy. Patients and providers need to consider all of the evidence when weighing the pros and cons of psychotherapy or medications for the treatment of depression. Although pharmacotherapy might be more widely available to patients through primary care physicians, the research is suggesting that enduring effects and treatment compliance are higher among those who have access to psychological interventions.